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Dectin-1 Exerts Dual Control in the Gut.

TitleDectin-1 Exerts Dual Control in the Gut.
Publication TypeJournal Article
Year of Publication2015
AuthorsIliev ID
JournalCell Host Microbe
Volume18
Issue2
Pagination139-41
Date Published2015 Aug 12
ISSN1934-6069
Abstract

Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.

DOI10.1016/j.chom.2015.07.010
Alternate JournalCell Host Microbe
PubMed ID26269949
PubMed Central IDPMC4605567
Grant ListDK098310 / DK / NIDDK NIH HHS / United States
K99 DK098310 / DK / NIDDK NIH HHS / United States