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Genetic Approaches to Facilitate Antibacterial Drug Development.

TitleGenetic Approaches to Facilitate Antibacterial Drug Development.
Publication TypeJournal Article
Year of Publication2015
AuthorsSchnappinger D
JournalCold Spring Harb Perspect Med
Volume5
Issue7
Paginationa021139
Date Published2015 Feb 13
ISSN2157-1422
KeywordsAntitubercular Agents, Drug Design, Humans, Mycobacterium tuberculosis, Tuberculosis
Abstract

Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell screening hits and facilitate target-driven strategies for antimicrobial drug development.

DOI10.1101/cshperspect.a021139
Alternate JournalCold Spring Harb Perspect Med
PubMed ID25680982