|Title||Genetic Approaches to Facilitate Antibacterial Drug Development.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Journal||Cold Spring Harb Perspect Med|
|Date Published||2015 Feb 13|
|Keywords||Antitubercular Agents, Drug Design, Humans, Mycobacterium tuberculosis, Tuberculosis|
Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell screening hits and facilitate target-driven strategies for antimicrobial drug development.
|Alternate Journal||Cold Spring Harb Perspect Med|