You are here

The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.

TitleThe metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
Publication TypeJournal Article
Year of Publication2016
AuthorsRamos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH
JournalOncotarget
Volume7
Issue29
Pagination45597-45607
Date Published2016 Jul 19
ISSN1949-2553
Abstract

cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein.

DOI10.18632/oncotarget.10056
Alternate JournalOncotarget
PubMed ID27323809
PubMed Central IDPMC5216745
Grant ListK08 CA160657 / CA / NCI NIH HHS / United States
R01 GM107442 / GM / NIGMS NIH HHS / United States
T32 CA062948 / CA / NCI NIH HHS / United States