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Mycobacterial genes essential for the pathogen's survival in the host.

TitleMycobacterial genes essential for the pathogen's survival in the host.
Publication TypeJournal Article
Year of Publication2015
AuthorsEhrt S, Rhee K, Schnappinger D
JournalImmunol Rev
Volume264
Issue1
Pagination319-26
Date Published2015 Mar
ISSN1600-065X
KeywordsAnimals, Diet, Genes, Bacterial, Host-Pathogen Interactions, Humans, Microbial Viability, Mutation, Mycobacterium tuberculosis, Tuberculosis, Vitamins
Abstract

Mycobacterium tuberculosis (Mtb) has evolved within the human immune system as both host and reservoir. The study of genes required for its growth and persistence in vivo thus offers linked insights into its pathogenicity and host immunity. Studies of Mtb mutants have implicated metabolic adaptation (consisting of carbon, nitrogen, vitamin, and cofactor metabolism), intrabacterial pH homeostasis, and defense against reactive oxygen and reactive nitrogen species, as key determinants of its pathogenicity. However, the mechanisms of host immunity are complex and often combinatorial. Growing evidence has thus begun to reveal that the determinants of Mtb's pathogenicity may serve a broader and more complex array of functions than the isolated experimental settings in which they were initially found. Here, we review select examples, which exemplify this complexity, highlighting the distinct phases of Mtb's life cycle and the diverse microenvironments encountered therein.

DOI10.1111/imr.12256
Alternate JournalImmunol. Rev.
PubMed ID25703569
PubMed Central IDPMC4339221
Grant ListR01 AI09179 / AI / NIAID NIH HHS / United States
R01 AI063446 / AI / NIAID NIH HHS / United States
R01 AI092573 / AI / NIAID NIH HHS / United States
R01 AI091790 / AI / NIAID NIH HHS / United States
R01 AI63446 / AI / NIAID NIH HHS / United States