I received my undergraduate degree from Sun Yat-sen University in 2009 with a major in biochemistry. Before I came to NYC, I spent two years in National Institute of Biological Sciences (NIBS) working as a research assistant in Dr. Wenhui Li's lab. My research in NIBS focused on pathogenesis of Chlamydia and hepatitis B virus (HBV).
I started my graduate study at Weill Cornell in August 2011 and did my first rotation in Dr.Sabine Ehrt's lab, working on the thioredoxin system of Mycobacteria. I formally joined her lab in the summer of 2012 and am now continuing my project on studying the thioredoxin system ofMycobacterium tuberculosis.
Uday S. Ganapathy
I am from Malaysia. I earned a B.A. in Biological Sciences from Cornell University in 2008. While an undergraduate at Cornell, I did research in the lab of Dr. Siu Sylvia Lee where I studied the genetic basis of longevity using C. elegans as a model organism. I was accepted into the Immunology and Microbial Pathogenesis Program at the Weill Cornell Graduate School of Medical Sciences in 2008. I joined Dr. Sabine Ehrt's lab in June 2009 and have since been studying the role of gluconeogenesis in the pathogenesis of Mycobacterium tuberculosis.
Susan E. Puckett
Susan Puckett graduated from Oregon State University in Corvallis, Oregon with a degree in microbiology in 2008. There she worked in the lab of Dr. Bruce Geller on antisense antibiotic development and testing in Escherichia coli. After moving to New York City in Jan. 2009, she joined the lab of Dr. Sabine Ehrt as a laboratory technician and in Jul. 2010 as a graduate student. Her current focus is on drug target validation of enzymes involved in central carbon metabolism inMycobacterium tuberculosis (Mtb). This work involves development of conditional knockdown and knockout Mtb mutants and using them to determine the importance of specific carbon metabolism genes in vitro and in the mouse model of tuberculosis. Furthermore, she is investigating the mechanisms of death of carbon metabolism mutants and aims to enhance understanding of regulation of carbon metabolism in Mtb.
Puckett, S., Trujillo, C., Eoh, H., Marrero, J., Spencer, J., Jackson, M., Schnappinger, D., Rhee, K., Ehrt, S. (2014). Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. Manuscript submitted for publication.
Puckett, S.E.*, Reese, K.A.*, Mitev, G.M., Mullen, V., Johnson, R.C., Pomraning, K.R., Mellbye, B.L., Tilley, L.D., Iversen, P.L., Freitag, M., and Geller, B.L. (2012). Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers. Antimicrob Agents Chemother 56, 6147-6153.
*Contributed equally to this work
de la Paz Santangelo, M., Gest, P.M., Guerin, M.E., Coincon, M., Pham, H., Ryan, G., Puckett, S.E., Spencer, J.S., Gonzalez-Juarrero, M., Daher, R., Lenaerts A.J., Schnappinger, D., Therisod, M., Ehrt, S., Sygusch, J. and Jackson, M. (2011). Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. J Biol Chem 286, 40219-40231.
I am Ruojun from Shanghai, China. I received my B.S. degree in life science from Fudan University right before I joined Weill Cornell Graduate School in 2012. I became a member of Dr. Sabine Ehrt's lab in 2013, and started my thesis project on Mycobacterium tuberculosis.
I received a BSc in Life Sciences from the National University of Singapore(NUS) in 2010; as an undergraduate in NUS, I spent two years in the lab of Dr. Sylvie Alonso studying the pathogenesis of Mycobacterium bovis BCG. I joined the Weill Cornell Graduate School of Biological Sciences in 2010, and started working in the lab of Dr. Sabine Ehrt in 2011. I am currently performing transposon library screens to identify genes involved in the pathogenesis of Mycobacterium tuberculosis.
Christina Maksymiuk is from Detroit, MI and graduated with a BS in Chemistry from Carnegie Mellon University in 2008. She joined Carl Nathan’s lab at Cornell in December of 2010, where her research focused on characterizing 2-hydroxy-3-oxoadipate synthase (HOAS) in Mycobacterium tuberculosis. She is defending her thesis on November 5 of this year!
Maksymiuk C, Chikacherla G, Gil, RR, Donahue NM. Secondary organic aerosol formation from multiphase oxidation of limonene by ozone: mechanistic constraints via two-dimentional NMR spectroscopy. Phys. Chem. Chem. Phys., 2009, 11, 7810.
Bryk R., Arango, N, Maksymiuk, C, et al. Lipoamide channel-binding sulfonamids selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry, 2013, 52 (51), 9375-9384.
Michelle Siao is characterizing transcriptional and epigenetic control of antigenic variation in the malaria parasite. An MD-PhD candidate and National Defense Science and Engineering Graduate Fellow, she began research on RNA processing while at Harvard College. Her interests include molecular biology, medicine, education, technology, and global health.
Meredith Wright is from West Orange, NJ and graduated from Princeton University in 2013 with a degree in Molecular Biology. She started the Immunology & Microbial Pathogenesis PhD Program at Weill Cornell in the fall of 2013 and joined the Ehrt lab in the summer of 2014. Meredith is passionate about the issue of antibiotic resistance and hopes that her time in the Ehrt lab will allow her to contribute to the discovery of novel strategies for fighting tuberculosis.
Infectious diseases have always fascinated me! I received my B.Sc in Microbiology from St. Xavier’s College, Kolkata, India. I earned my Masters in Virology (Gold medalist) from National Institute of Virology, Pune, India. I worked on molecular characterization of Dengue viruses for my M.Sc. dissertation. I came to USA in 2011 and joined the Immunology and Microbial Pathogenesis program at Weill Cornell Graduate School of Medical Sciences. I joined Dr. Carl Nathan’s lab in 2014. Broadly, I am interested in host-directed therapy against tuberculosis. I am currently investigating the molecular pathways that enhance macrophage activation upon protein kinase R inhibition.
Susannah Calhoun is from Brooklyn, NY and graduated from Smith College with a B.A in Biological Sciences in 2010. She first became interested in parasitology while studying abroad at the University of Edinburgh. She was a research technician in the lab of Alessio Accardi at Weill Cornell from 2010 to summer 2012. After starting the Immunology & Microbial Pathogenesis program in fall 2012, she joined Kirk Deitsch's lab. Her research focuses on characterizing the mechanisms of var gene recombination in Plasmodium falciparum, the parasite that causes malaria.